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Parallel assessment of inflammatory markers, cortisol, oxidative stress indices, and neurotrophic factors such as BDNF would enable evaluation of biological target engagement and differential mechanistic effects

This is achieved through downregulation of -catenin transcription factor-7-like-2 (TCF7L2) mRNA and suppression of downstream Wnt/-catenin signaling target genes, including Cyclin D1, c-Myc, Snail, Vimentin, matrix metalloproteinase 2 (MMP2), and MMP9, in human CRC cells (Pooja et al., 2014)