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"L-carnitine for insulin resistance: meta-analysis." Adv Clin Exp Med 2017;26:333-8

Since ER and AR are both required for the correct functioning of the adult male brain, it is interesting therefore that pituitary downregulation ADT, which significantly lowers circulating testosterone, may have more of an effect on the brain, due to diminished T to E2 conversion, whereas androgen antagonists such as bicalutamide may only inhibit the AR-mediated effects in the brain

Muscle carnitine content was normal, but the patient was on L-carnitine supplementation at the time of biopsy (data not shown)

Clarke R, Peden JF, Hopewell JC, Kyriakou T, Goel A, Heath SC, et al