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The term alkyl (or lower alkyl) as used throughout the specification, examples, and claims is intended to include both unsubstituted alkyls and substituted alkyls, the latter of which refers to alkyl moieties having one or more substituents replacing a hydrogen on one or more carbons of the hydrocarbon backbone

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doi: 10.1677/joe.0.1570099 59 NagayaN.KojimaM.UematsuM.YamagishiM.HosodaH.OyaH.et al

Perimenopause of course is a natural phase before menopause when a womans body starts shifting, causing irregular periods, mood swings, and other changes due to fluctuating hormone levels, marking the transition to the end of reproductive years