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ROS generated by the Fenton reaction tends to react with phospholipids (PL) to form hydroperoxy-phospholipids (PLOOH), which are the main elimination target of GPX4 (Wiktorowska-Owczarek et al., 2015)

This distal ROS spread correlated with rapid trafficking of oxidized mitochondria toward distal regions of the cell (Supplementary Movie 3), but mitochondrial motility across the cell was rarely visualized ( ~ 13% of total photostimulations) in our experimental timescale

ALA primarily acts as a multifunctional redox modulator and mitochondrial cofactor, UA promotes mitochondrial quality control through mitophagy and mitochondrial biogenesis, and EGT functions as a stable cytoprotective antioxidant with selective cellular uptake

Just think about fluid pressure in a small container being pushed, pushed, pushed until the can or the container is ready to explode, and how multiple features, multiple variables could impinge on that and create that pressure