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Initial Treatment in Combination with Pembrolizumab and Platinum The efficacy of pemetrexed in combination with pembrolizumab and platinum chemotherapy was investigated in Study KEYNOTE-189 (NCT02578680), a randomized, multicenter, double-blind, active-controlled trial conducted in patients with metastatic non-squamous NSCLC, regardless of PD-L1 tumor expression status, who had not previously received systemic therapy for metastatic disease and in whom there were no EGFR or ALK genomic tumor aberrations

The ability of MSCs to promote tissue regeneration, decrease inflammation, and differentiate into Schwann cells in specialized in vitro conditions 7 support the hypothesis that these cells may positively influence nerve regeneration outcomes in the setting of limb transplantation

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