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In the other direction, the brain may exert an influence on the gut, either via the autonomic and enteric nervous systems (downwards black arrows in Figure 2 ), or via activation of the Hypothalamus-Pituitary-Adrenal (HPA) axis (downwards red arrows in Figure 2 ), which will be examined in detail later

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Simultaneously, addressing agglomeration and stability challenges requires innovative GO composite designs, such as embedding GO in aerogels or covalent organic frameworks to enhance mechanical integrity and facilitate recyclability 355