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Deletion of SREBP2 in the liver reduced the amount of LDLr mRNA by approximately 20% but there was an accompanying approximately 80% reduction in the mRNA level of PCSK9

10.1038/s41396-020-0679-2 ISME J

Furthermore, a cKO model of HGF deregulation, in which HGF was deleted from a limited number of tissues including cochlea, was associated with extensive cochlear pathology with morphogenetic defects and non-progressive deafness (Schultz et al., 2009)