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Many Small unmyelinated axons (Yellow): Fewer than in sural nerve Neurofilament stain (Green) NCAM stain (Red) Infraorbital Nerve : P 0 (Red) Prominent in myelin (Red) around most (large & small) myelinated axons Smallest axons (Green) have no myelin or associated P 0 staining Neurofilament stain (Green) P 0 stain (Red) Infraorbital Nerve Myelin basic protein (MBP) is markedly reduced in myelin around axons compared to sural nerve Neurofilament stain (Green) Myelin basic protein stain (Red) P 0 stain (Green) Myelin basic protein stain (Red) VvG stain Nerve: Infant Toluidine blue stained plastic sections Nerves from Infants Axons are mildly small Myelin sheaths around large axons are moderately thin Compare to: Adult Toluidine blue stained plastic sections Nerve from neonate Few axons are myelinated

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Clinics offering both should clearly explain which services may qualify for insurance and which do not

Lukassen S, Chua RL, Trefzer T, Kahn NC, Schneider MA, Muley T, et al