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Thrombus formation and the subsequent activation of the coagulation cascade with final generation of fibrin is facilitated by the mCRP-mediated enhancement of tissue factor on the endothelial cell surface, platelet aggregation and thrombus growth (207, 208) (Figure 7)

1 Introduction Alzheimers disease (AD) is a progressive and multifactorial neurodegenerative disorder that predominantly affects the elderly population, manifesting as severe cognitive decline, memory impairment, and behavioral disturbance (Tripathi et al., 2024)

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[23] In one study, when NAC was added to rat bone marrow cultures, significant improvements were seen in the activity of alkaline phosphatase (levels of which increase when bones are growing) and osteoblastic cultures (cells that develop bone), as well as an upregulation of bone-related gene markers such as collagen