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Furthermore, while some reports have shown that SARS-CoV-2 can actively infect primary human monocytes, resulting in NLRP3 activation and IL-1 secretion (85, 86), in the present study we were unable to detect productive infection of primary human HC monocytes by SARS-CoV-2 in vitro ( Supplementary Figure 4 ), although SARS-CoV-2 exposure was sufficient to promote NLRP3-driven IL-1 production