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Folia Morphologica 2005 64:3 (233-236) Dubey J.P., Bhaiyat M.I., De Allie C., Macpherson C.N.L., Sharma R.N., Sreekumar C., Vianna M.C.B., Shen S.K., Kwok O.C.H., Miska K.B., Hill D.E., Lehmann T

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278 In addition to promoting tumor proliferation, STAT3 contributes to GBM aggressiveness by promoting EGFRvIII-mediated invasion through JAK2/STAT3 signaling and stabilizing focal adhesion complexes

Specifically, ALDH3A1 enhances glycolysis to promote the cell proliferation of NSCLC by activating the HIF-1/LDHA pathway, whereas this effect could be suppressed by -elemene in vivo