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Geijer, M

Ghezzo A, Salvioli S, Solimando MC, Palmieri A, Chiostergi C, Scurti M, Lomartire L, Bedetti F, Cocchi G, Follo D, Pipitone E, Rovatti P, Zamberletti J, Gomiero T, Castellani G, Franceschi C

In a rodent model simulating the passive transfer of anti-NMDAR encephalitis, characterized by seizures and cognitive impairments, anakinra treatment led to a rapid decrease in seizure activity within 24 to 48 hours, improved memory function, and a notable reduction in indicators of microglial and astrocytic activation [72]

The result showed that mutations at sites of K38, K126, or K326 substantially decrease the succinylation level of GCLC, and simultaneously mutating all these three sites led to a nearly undetectable level of succinylation modification (Figs