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Figure 1 Despite recent progress, the mechanistic links between circadian rhythms and BBB dynamics remain incompletely understood, and current animal models are limited by interspecies physiological differences

With advances of studies, many new regulators related to ferroptosis have been confirmed, such as ACSL4[61], bone morphogenetic protein-7 (BMP7)[164] and ZRT/IRT-like protein 14 (ZIP14)[126], which will further promote the understanding of the regulatory mechanism of ferroptosis and provide promising directions for expanding novel drugs for the treatment of kidney diseases in the future

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A routine B-12 shot can stabilize mood and serve as an effective measure to help prevent depressive relapses