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However, a high incidence of MS has been found in the major medical herb-producing countries, and it is increasing, with many cases in adolescence (Hashem et al., 2010

Knockdown efficiency was shown by immunoprecipitating PTPN22 from cell lysates using PTPN22 antibody, followed by immunoblot analysis of anti-PTPN22 immunoprecipitates and whole cell lysates with specific antibodies

These changes are accompanied by increased uptake of tumor-derived exosomes and stabilization of pro-tumoral signaling pathways that reinforce microglial support of tumor growth (325)

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