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Inhibition of intestinal epithelial cell necroptosis with HIF1a stabilizers or RIPK3 inhibitors [1] and strengthening the integrity of TJs with zonulin inhibitors or butyrate [2] have recently emerged as attractive therapeutic approaches to control arthritis (Fig

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Eight months after partially tearing his Achilles tendon, he could manage daily activities, but his recovery had slowed down

Heme oxygenase-1 (HO-1), a cytoprotective enzyme, was upregulated upon treatment with erastin or RSL3 in renal proximal tubule cells, while deletion of HO-1 increased the cellular susceptibility to erastin-induced ferroptosis [37]