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The heavy chain of the C34 Fab engages the CHIKV E1E2 heterodimer with a buried surface area of 573 , while the light chain buries an area of 622 , resulting in a total buried interface of 1195

On the other hand, a pH that registers above 7 is indicative of a larger concentration of OH ions relative to H and thus suggests heightened alkalinity

13,20 Discussion The dermatosparaxis type of EDS is a rare but severe autosomal recessive heritable connective-tissue disorder resulting from disturbed processing of type I procollagen N-propeptide due to biallelic loss-of-function mutations in ADAMTS2 encoding the most important type I procollagen N-endopeptidase