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(PubMed) Seshadri S, Beiser A, Selhub J, et al

As fat cells expand, they begin to produce more NNMT, an enzyme that disrupts normal metabolic function

Calculating concentrations and drawing correct volumes is not always straightforward, especially when working with vials of different sizes, variable amounts of bacteriostatic water, and unique research dosing goals

The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study