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To find out why, researchers tested the liver cells to see what had changed in the depressed mice

doi:10.1016/j.jneuroim.2008.09.005 Ilhan N, Kamanli A, Ozmerdivenli R (2004) Variable effects of exercise intensity on reduced glutathione, thiobarbituric acid reactive substance levels, and glucose concentration

These observations are consistent with the hypothesis that NFT activates Nrf2, leading to increased GCL synthesis, and subsequently, to a rise in intracellular glutathione levels