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Cardiac ischemia-reperfusion cardioprotection models, infarct size reduction, post-ischemic mitochondrial function Heart failure with preserved ejection fraction (HFpEF) Phase II and Phase III clinical trial contexts (Elamipretide) Renal ischemia-reperfusion and acute kidney injury cardiolipin interaction as the mechanistic anchor Mitochondrial aging and sarcopenia preservation of bioenergetic capacity in muscle tissue models Neuroprotection and neurodegenerative models oxidative stress reduction at the mitochondrial site Barth syndrome (genetic cardiolipin disorder) Phase II/III clinical context with highest mechanistic specificity Metabolic dysfunction and mitochondrial disease broader disease contexts where ETC impairment is central SS-31 selectively binds cardiolipin on the inner mitochondrial membrane, preventing ROS-induced peroxidation and preserving cristae architecture

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J Leukoc Biol (2008) 83:148492