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864 Downregulation of the antioxidant defense system has been noted in OA patients, evidenced by decreased levels of GSH and its oxidized form GSSG in their synovial fluid

MDA is a relatively stable oxidizing molecule that shows similar cytotoxicity and mutagenic potential with 4-HNE, reacting with various proteins and biomolecules

Pterins as diagnostic markers of exercise-induced stress: a systematic review

Second-line treatment includes rational application of vasoconstricting active drugs and other diuretics, such as tovaptan (Pratama et al., 2024) and terivasopressin (Ding et al., 2024)