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The findings reflect a peptide with broad protective and repair focus

Upon the cleavage, positively charged primary amines are generated, facilitating the effective crossing of the nanoprobe through BBB via the adsorption-mediated transcytosis pathway, while avoiding the caveat of cationic toxicity

The vasoconstrictive effect of Ang II is even more pronounced as the vasodilatation of the RAAS axis ACE2/Ang 1-7/AT 2 R is attenuated, and the expression/activation of endothelial nitric oxide synthase (eNOS) is reduced due to OS

A total of 17.6 l of the transfection mix was added to each well already containing 3.6 l siRNA (or 3.6 l water for mock controls), and the mixture was incubated at room temperature for 30 min