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However, transcript levels of pro-inflammatory cytokines were not significantly different between vehicle and roxadustat treated mice in both healthy and stroke-affected brain (Figure S4A) suggesting that systemic roxadustat treatment neither promotes inflammation in the intact CNS nor affects the local pro-inflammatory response during acute ischemic stroke

In fact Lang and coworkers have recently studied eryptosis on young and old human RBC and confirmed that PS exposure was similarly negligible in young and old RBC, but increased upon induction of eryptosis more so in old than young RBC (Ghashghaeinia et al., 2012)

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