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Kenneth McCall, published a paper in 2025 finding that compounded GLP-1s were linked to higher rates of adverse effects than non-compounded products between 2018 and 2024, including more abdominal pain, diarrhea, and nausea

Numerous microbial species that may produce neurotransmitters, signaling chemicals, or metabolize their precursors into various substances can be found in the human microbiome (163165), during food fermentation and bacterially altered host molecules including bile acids (BAs) (166), tryptophan metabolites, and SCFAs with CNS effects are also produced by the gut bacteria