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In one study, some researchers used a CRISPR/Cas9 knockout screen to identify 10 drug-resistant genes, including C1orf115, a previously uncharacterized MDR gene that they named required for drug-induced death 1 (RDD1) (463)

10.1093/humrep/dead093.872 33 PeiJ.PanX.WeiG.HuaY

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Research has shown that reaching a cumulative dose in the range of about 120 to 150 mg per kilogram is associated with the most durable results, and going higher than that doesnt reliably add benefit