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However, even when sufficient tumor-specific T-cell clones are present, their functional state and differentiation fate within the immunosuppressive TME are equally critical, as an unsustainable immune response ultimately leads to treatment failure

3b indicated a strong GoH3-induced reduction of growth

However, neurodegenerative disease mechanisms differ substantially between animal models and human diseases, and premature clinical use based solely on animal data could expose patients to unknown risks without established benefits