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In terms of fatigue, depression and anxiety, all of those improved, on average, for the intervention group, while slightly increasing for the control group

382,383 An in-depth understanding of the underlying mechanisms of cellular pyroptosis is essential to determine its role in the pathogenesis of DPN and develop effective therapeutic agents targeting the pyroptosis signaling pathway to alleviate neuropathic symptoms

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19 However, this intervention faces challenges of safety and limited efficacy for inducing rejuvenation in vivo