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The first thing to keep in mind is when you schedule your procedure, make sure you dont have any important work or social events for about a week just to be safe

B12 bound to HC is not taken up by cells and thus, is biologically inactive ( via endocytosis using a specific CD320 receptor (Quadros, 2010)

Treating true deficiency can improve deficiency-related symptoms (including anemia-related fatigue and neurologic issues) (see the NIH ODS Vitamin B12 fact sheet )