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126 A breed predisposition has been suggested for Doberman Pinschers (sulfonamides, amiodarone, diethylcarbamazine/oxibendazole) and Labrador Retrievers (carprofen), which may be a reflection of a genetic predisposition.21, 71, 73, 134, 137 Clinical Examination The spectrum of drug- and toxin-induced liver injury and, thus, the associated clinical presentation, can vary from subclinical hepatic injury with only increased serum liver enzyme activity, to severe liver damage manifested as ALF, or chronic end-stage liver disease

Subsequently, assuming an API concentration of 50 mcg/100 mg of formulation (Drugs.com, 2023), the mean API mass delivered at the nasopharynx through direct inhalation would be 0.92 mcg for IU and 0.024 mcg for CU

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