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With the onset of IDD, IVD, especially NP, undergoes a progressive dehydration due to proteolytic cleavage of aggrecan together (Karppinen et al., 2011), a substantial reduction of resident cell viability (Vergroesen et al., 2015)

Efforts are ongoing to evaluate the safety and effectiveness of various CAM therapies through more rigorous research methodologies

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Vitamins fit into two major categories: fat-soluble and water-soluble