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Ferguson, E.L

Scholze A, Rinder C, Beige J, Riezler R, Zidek W, Tepel M (2004) Acetylcysteine reduces plasma homocysteine concentration and improves pulse pressure and endothelial function in patients with end-stage renal failure

So, they distinguish these studies from studies that rely on less reliable screening tools

(Wikipedia) In senescent cells (cells that have permanently exited the cellcycle, accumulate damage, and secrete inflammatory factors), FOXO4 expression goes up and helps bind p53 in the nucleus, preventing p53 from driving those cells into apoptosis