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This was particularly important to ensure the concentration of NADPH was known for acidic conditions where loss of NADPH due to cyclization is expected (Wu et al., 1986)

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Subsequently, research from the 1980s and 1990s consistently found that suppression of melatonin via continuous light exposure increased susceptibility to chemically induced mammary tumors, while exogenous melatonin conferred protective effects 47,48,49,50,51