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If your chronic fatigue seems to get better only with adenosyl B12 (and not with methyl B12), its possible that you have some rare condition preventing your body from the inter-conversion

28 Co-occurring conditions like anxiety, depression, stress, and sleep disorders can be contributors, while disturbances that are difficult to diagnose, such as dysregulated stress reactivity, neurotransmitter imbalance, inflammation, mitochondrial dysfunction, free radical damage, hormonal imbalance, and metabolic disturbance, as well as crosstalk between these factors, may also play a role

Parkinson's disease and movement disorders

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