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This activation contributed to the acquisition of stem-like features and promotes therapeutic resistance ( FIGURE 4 4.2 Upregulation of ATP-binding cassette (ABC) transporters and drug efflux Overexpression of ATP-binding cassette (ABC) transporters actively expels therapeutic agents from cancer cells (Zhong et al., 2024)

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Also, other researchers have measured decreased SOD activity in the lenses of patients with senile and diabetic cataract 66