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173 Activation of mTORC1 enhances metabolic pathways, including glycolysis, the oxidative branch of the pentose phosphate pathway, and de novo lipid biosynthesis

Importantly, focal methylation variability generates transcriptionally distinct subpopulations within the same tumor., In addition to DNA methylation, non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, collectively add an additional layer of post-transcriptional regulation, that contributes to heterogeneous therapeutic responses (9093)