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There is also evidence that deficiencies in copper and pantothenate decrease levels of complex IV (Brambl & PlesofskyVig, 1986

5 Discussion Cardiovascular medicine is experiencing a paradigm shift from experience-based practice to precision medicine, owing by the emergence of three fundamental pillars: omics technologies, AI, and personalized nursing

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Activation of the TMAO-induced endothelial NLRP3 inflammasome was reduced by a mitochondrial ROS scavenger or SIRT3 overexpression in human umbilical vein endothelial cells (HUVECs), which suggested that the activation was mediated in part by inhibition of the SIRT3-SOD2-mtROS signaling pathway (Zhou et al., 2010