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The MS operational parameters and data analysis are the same as for the metabolite analysis Body water enrichment and DNL calculation To quantify body water enrichment, 5 l of serum, 5 l of water, 4 l of 1 M sodium hydroxide and 10 l of acetone were mixed in a glass vial and incubated overnight at room temperature to promote 2 H exchange between 2 H 2 O in serum and acetone 94

Campos Y, Arenas J

Untreated cells were labelled with DANSO 2 H to exclude unspecific reactions in vivo of our probe with membrane lipids, suggesting that our probe is specific for lipid N -chloramines (Figure 5B)