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Because of the similarity in the pathomechanism of different SNHLs and the known DAergic [82], anti-apoptotic [24], anti-oxidant [25], neuroprotective [26] and immunmodulatory actions [27] of selegiline, we initiated a study on the effects of selegiline and its analogues on DA release from LOC terminals in the mouse cochlea and in an AGIHL mouse model

Therefore, the present systematic review aims to comprehensively evaluate preclinical evidence regarding the neuroprotective effects of curcumin, piperine, and their combined or nanoformulated interventions in models of neurodegeneration, neurotoxicity, aging, oxidative stress, and neuroinflammation