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49 In bovine pulmonary arteries, hypoxia was shown to reduce cartilage oligomeric matrix protein expression in the ECM, decrease BMPR2 protein levels, downregulate SOD2 expression, increase reactive oxygen species (ROS), and inhibit the contractile phenotype of PASMCs

2010;15(Suppl 2):504

From the vantage point provided by phosphoproteomics, it appears likely that multiple, potentially independent signalling alterations mediate insulin resistance