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Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification

S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice

E.TognoliniM.BorgesG.CrozierA

To measure the forward reaction rates, we mixed RT (10 M) with equal volumes of different concentrations of GSH solutions (5, 10 and 20 mM) at pH 7.4 and monitored the formation of RT-GSH using a fluorimeter ( ex =405 nm