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The MHRA has issued warnings about unlicensed injectable products, particularly those obtained online or administered in non-clinical settings, due to concerns about contamination, incorrect dosing, and lack of quality assurance

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This challenge is particularly relevant for nanoparticle-based delivery systems, whose disposition is often formulation-dependent and may involve prolonged circulation, nonlinear pharmacokinetics, and extensive tissue distribution that are not adequately captured by conventional scaling assumptions (Valic and Zheng, 2019)

This effect was observed despite a more favorable plasma lipid profile and increased insulin sensitivity