Rat peritoneal mast cells were also treated with pterostilbene (1, 10, 50, 100 M) and no effect on cell viability was observed, however degranulation and IL-6 expression was inhibited [209]
According to data from the World Health Organization, approximately 225,000 new ovarian cancer cases are reported globally each year, with HGSOC accounting for the vast majority, and its mortality rate ranking among the highest of all gynecological malignancies ( HGSOC is typically diagnosed at an advanced stage, a phenomenon that results in an extremely poor prognosis, as the absence of early diagnosis and effective treatment contributes to a continuous increase in mortality rates ( The clinical manifestations of HGSOC are typically not apparent in the early stages, with patients potentially experiencing non-specific symptoms such as abdominal distension, abdominal pain, decreased appetite, and weight changes, which render early diagnosis particularly challenging
Glutathione, often referred to as the body's master antioxidant, is found in every cell and is crucial for combating oxidative stress, detoxifying harmful substances, and maintaining cellular health
Response: We thank the commenters for raising this aspect of the measure
