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The activated LATS1/LATS2 bind to the cofactor MOB1 and phosphorylate the downstream transcriptional coactivators YAP and TAZ (see Figure 2)

25 , 26 , 31-37 In an often quoted DACOTA randomized clinical trial comparing HU (N=86) to DAC (N=84), overall responses were 35% and 63%, respectively, median OS 18.4 and 21.9 months, median event-free survival 10.3 and 12.1 months, and 2-year BT rates 38.4% and 60.7%