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Specifically, the upregulation of the Nrf2 pathway triggers the production of phase II detoxifying/antioxidant enzymes, such as HO-1 and GSTa, while the downregulation of the TLR2/MyD88/NF-B pathway results in a decreased production of pro-inflammatory cytokines, including IL-1, IL-8, and TNF-

doi: 10.1007/s00210-011-0610-5

Statements Author contributions HS: Writing review & editing, Writing original draft

Although these results are not statistically significant and only a trend for an effect has emerged, in the case of fipronil, the results are highly consistent with those of a previous study clearly showing the effects of insecticide on both sperm concentration and metabolism with similar disorders 20, 58