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51 As GSH is known to be present in CSF at very low concentrations (~0.2 mol/l in both healthy and PD subjects), 52 relative to brain tissue concentrations (~1 mmol/l), 7 LCModel-calculated Cr concentrations ( C measured ) were corrected ( C corrected ) using the following formula, which assumes negligible contribution of CSF GSH to the total GSH signal: Absolute GSH levels (IU) were calculated by multiplying GSH/Cr ratios by CSF-corrected absolute Cr concentrations (IU)

Longitudinal analysis of contrast acuity in Friedreich ataxia

Food and Nutrition Department

In order to test, if one of these ABC transporters is needed to import reduced glutathione, we deleted genes coding for one of the permease domains (OppC, DppC and SapC) or the periplasmic binding protein in case of Yej (YejA) in cells lacking glutathione biosynthesis and the GsiC permease