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Research Gaps and Future Directions# The sleep-peptide field has notable research gaps: No modern RCTs for DSIP -- the most direct sleep peptide lacks contemporary clinical trials using current polysomnographic methodology No sleep-specific studies for GH secretagogues -- while the GH-sleep connection is well-established, no study has specifically measured sleep outcomes (rather than GH levels) for ipamorelin, sermorelin, or CJC-1295 Limited independent validation for bioregulators -- epitalon and pinealon research remains concentrated in the Khavinson group, with minimal independent replication No head-to-head comparisons -- no study has compared any of these peptides against each other or against established sleep interventions Sleep architecture vs