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71,72 In a randomized controlled trial that included 34 people with primary open-angle glaucoma, adding 30 mg aqueous saffron extract daily to standard treatments for one month reduced intraocular pressure more than placebo

Their protective functions include reducing paracellular permeability, boosting innate immune responses against pathogens, and consolidating the physical barrier provided by the mucous layer (163)

Biotin has been added because chronic administration of lipoic acid lowers the activities of pyruvate carboxylase and beta-methylcrotonyl-CoA carboxylase in vivo by competing with biotin.*

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