It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
The combination of (-)-Vestitol and Salviolone synergistically regulated more genes and pathways related to AD To elucidate the underlying MOA for the synergistic effects of the combination of (-)-Vestitol and Salviolone, we performed RNA-seq analysis on the cortex of the WT, control, (-)-Vestitol, Salviolone, and combination groups
The severity of these effects is influenced by genetic predisposition, individual metabolic differences, and variations in drug pharmacokinetics (Rivetti et al
Biologically Active Lignans in Extract and Seeds of Schizandra Chinensis. Pharm Chem J Pharmaceutical Chemistry Journal 41.2 (2007): 94-96
