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CNS Neurosci Ther 30(2):e14617

The exosomal alterations can provide new insights regarding the disease progression, therapeutic response and resistance features

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Furthermore, circulating aged neutrophils (CANs), a subset of neutrophils with high surface expression of CXCR4 and low CD62L and participate in the VOC process, are also higher in SCD [37, 45, 49]