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ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer

(ii) GxG (Gene x Gene) interaction, wherein the loss of two genes leads to a fitness phenotype that is not the simple additive sum of two single KOs, and (iii) GxGxE (Gene x Gene x Environment) interaction, wherein the impact of the pairwise genetic interaction is dependent on the metabolic state

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In addition, whortleberry, tangeretin, cynaroside, resveratrol, Dendropanax morbifera , troxerutin, and meclofenamic acid also have certain inhibitory effects on nephrotoxicity [128,129,130,131,132,133]