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The idea studied is whether two pathways together change the growth hormone pulse compared with one alone

Tesamorelin alone is FDA-approved as EGRIFTA for a narrow indication (HIV-associated lipodystrophy)

doi: 10.1021/acs.bioconjchem.9b00669 91 De JongWHBormPJ

According to previous literature, ATO can contribute to hepatotoxicity based on three factors: host-dependent risk factors, underlying disease, and drug-dependent risk factors